Muscimol Vs. Psilocybin: What's The Difference?

Muscimol Vs Psilocybin

Are you interested in exploring the world of mind-altering substances but not sure how to start the research process? You’ve come to the right place! That’s one of the reasons why we put together this guide - so that you can know more about the differences between muscimol and psilocybin. 

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Key Takeaways

  • Muscimol and psilocybin are both psychedelic compounds.
  • The effects between these two psychedelic substances can be similar, but they each have a few defining characteristics.
  • Both muscimol and psilocybin mushrooms can have both positive and negative effects.
  • Muscimol and psilocybin fall into different substance categories and they also can bring about different effects.

See Related: Is Marijuana Legal In Ohio?

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Getting to Know Mind-Altering Substances

Before we dive into the differences between muscimol and psilocybin, let’s go over one of their biggest similarities.

Both of these compounds (and the mushrooms they come from) fall within the mind-altering substance category. This means that they’re substances that can have a variety of different effects, including altering someone’s perception of reality and their overall mental state. 

Mind-altering substances can be dangerous, and using them is something that should be taken very seriously. If you’re considering ingesting either muscimol or psilocybin mushrooms, one of the best things you can do is research them and learn more about these compounds themselves. (Reading this article is a great place to start!)


As with all substances, there are many different safety concerns to think about when it comes to mind-altering options (remember that this category includes both muscimol and psilocybin).

It’s a good idea to have someone with you while you’re using psychedelics. Often referred to as a “trip sitter,” this person can be extremely helpful if you experience undesired effects or need some additional support. If you don’t have someone who can physically be with you, consider asking someone if they can text or call you to check in.

If you’ve used substances (especially mind-altering ones) in the past and had a negative reaction, you may want to pay attention to that warning. A negative previous reaction could point to the same thing happening again in the future, so it may be best for you to avoid these substances if that’s something you’ve experienced before.

We hope that these safety tips have been helpful as you learn more about both muscimol and psilocybin. Remember to only do what you feel comfortable with and research all your options before taking psychoactives or psychedelics. Once you’re ready to begin your journey into the world of mind-altering substances, prepare to experience novel sensations and undiscovered emotions. Mind-altering substances hold so much potential and exploring all your different options can help bring you closer to your health and wellness goals. 

Okay, let’s answer the question we’re all here for: what is the difference between muscimol and psilocybin mushrooms?

Bonus: Understanding The Different Types Of Psychedelic Mushrooms

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One of the most important things to think about when it comes to these substances is the dosage that you’re going to be taking. 

It’s typically recommended to remain conservative with dosages and start small. If you’re an experienced psychedelic enthusiast, you may be able to increase your dosage to get the effects that you’re looking for. However, if you’re new to the world of mind-altering substances, you might want to consider dipping your toe in the water before you jump to a higher dosage.

Keep in mind that different dosages will bring about different effects. If you’re looking for a more intense experience, then you will most likely want to opt for a slightly higher dose. With that being said, you should proceed with caution and only take an amount that you feel comfortable with.

When it comes to mind-altering substances, one of the biggest mistakes that you can make is taking too much because you haven’t felt the desired impacts yet. This could lead to uncomfortable effects. If you’ve already taken muscimol or psilocybin mushrooms and you’re not experiencing the effects that you are looking for, it may be best to wait for another day and try again.

Before you start using mind-altering substances, it’s best to research the specific substance and its potential negative effects. This can help you make sure that you’re aware of what could potentially happen and that you can prepare yourself for a variety of possibilities.

Keep in mind that the right dosage for someone else may not be the right choice for you, so it’s best to use your own personal judgment and make sure that you feel comfortable with what you’re taking.

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Understanding Muscimol vs. Psilocybin Mushrooms

Both muscimol and psilocybin are compounds that naturally occur in psychedelic mushrooms. However, there are a few key differences between them that are important to understand.

Muscimol Mushrooms

Muscimol comes from the Amanita muscaria mushroom. This mushroom has scarlet red caps and significant historical roots in multiple cultures, as shamans have used it in spiritual and religious rituals for hundreds of years. While this may not be the most well-known mind-altering mushroom, it’s one that you should be familiar with.

Many people think that muscimol falls within the psychedelic category, but that’s not the case. Though this substance acts very similarly to psychedelics, it’s actually a deliriant. This classification is due to the various biological receptors that this substance acts on, which are different from the receptors responsible for psychedelic effects.

Muscimol acts as a depressant. Muscimol targets GABA receptors, which is why it is able to produce mind-altering effects. While its effects on the mind are one of the primary reasons it’s used today, that hasn’t always been the case. Throughout history, this active compound has been used to relieve pain, calm inflammation, and reduce anxiety.

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Potential Effects of Amanita Muscaria Mushrooms

There may not be an overwhelming amount of research available abous muscimol, but there’s still plenty to learn.

Many people report that muscimol makes them feel euphoric. Others compare its effects to feeling like they’re in a dream. 

However, muscimol doesn’t agree well with everyone. In some cases, it can cause excessive sweating, defecating, and may even lead to temporary psychosis. 

While these are effects to be aware of, they’re not guaranteed. 

Everyone’s reaction to this substance is different, so it’s not possible to predict the way that you’ll react to it. Because of this, you should do your research before consuming this substance and make sure that you’re aware of its details.

Using muscimol can be a transformative experience. With that being said, dosage is an important factor to consider, as well as your individual metabolism and any past reactions that you’ve had to substances.

Psilocybin Mushrooms

The odds are that you have probably heard of psilocybin mushrooms. Unlike muscimol, psilocybin exists in many different kinds of psychedelic mushrooms. 

This compound falls within the psychedelic category. Psychedelic mushrooms that have this naturally occurring psychedelic agent are often referred to as “magic mushrooms.” Magic mushrooms are typically very versatile and can grow in many different types of environments. This is one of the reasons why they’re so popular within the psychedelic community.

When it comes to psilocybin mushrooms, it’s important to think about the type of mushroom you’re consuming. Each mushroom will have other chemicals in it besides psilocybin. These additional chemicals can impact the effects that you experience. Because of this, it’s best to be mindful and knowledgeable about your psychedelic options before you dive into this substance category.

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Psilocybin Effects

Psilocybin works with the brain's serotonin receptors, which results in the effects that many people associate with tripping. The brain works differently while under the influence of psilocybin, so this substance should be taken seriously and used cautiously. Many people report that they see things differently or feel things differently while under the influence of this compound.

Some people prefer to physically eat psilocybin mushrooms, while others prefer concentrated options. For most, the effects of this compound are felt within 30-60 minutes. Overall, the total effects should last for about 4-6 hours. However, this can depend on a variety of different factors, including your metabolism, overall health, substance use history, and more.

Taking psilocybin mushrooms at high doses could lead to unwanted effects, which is something to seriously consider if you’re not sure which dosage is right for you. Taking some time to think about the right dosage of psilocybin is essential, so give it some thought before your first (or next) magic mushroom experience.

Wrapping Up: Muscimol Vs. Psilocybin

Both muscimol and psilocybin mushrooms have the potential to alter your reality. With that being said, they do fall into two different substance categories.

If you’re looking for a spiritual or emotional transformation, then these substances could be right for you. It’s generally recommended that you only use one substance at a time, as combining them could be complicated and is a lot for your brain to process.

Staying safe is important when it comes to using mind-altering substances, so consider the best practices that we mentioned earlier (having a trip sitter, being mindful of your dosage, etc.).

Don’t hesitate to do your own research and learn more about these incredible compounds. As always, make sure to reach out to your doctor if you have questions about your own individual health or what options are right for you.

Keep Reading: How to Make Cannabutter: A Starter Guide


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